Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages

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منابع مشابه

Elucidation of anti-inflammatory constituents in Hypericum perforatum extracts and delineation of mechanisms of anti-inflammatory activity in RAW 264.7 mouse macrophages

105 Keyword Index 106 Introduction 106 Results/Discussion 108 Conclusions and Concluding Remarks 117 Experimental 117 Acknowledgements 122 Literature Cited 123 Tables 127 Figure Legends 131 Figures 133 CHAPTER 5. IDENTIFICATION OF PATHWAYS IMPORTANT FOR THE ANTI-INFLAMMATORY ACTIVITY OF AN HYPERICUM PERFORATUM FRACTION AND FOUR PUTATIVE BIOACTIVE CONSTITUENTS IN RAW 264.7 MOUSE MACROPHAGES USIN...

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Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells.

Hypericum perforatum (Hp) is commonly known for its antiviral, antidepressant, and cytotoxic properties, but traditionally Hp was also used to treat inflammation. In this study, the anti-inflammatory activity and cytotoxicity of different Hp extractions and accessions and constituents present within Hp extracts were characterized. In contrast to the antiviral activity of Hp, the anti-inflammato...

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Biosynthesis of the Active Hypericum perforatum Constituents

Extracts from Hypericum perforatum (St. John’s wort; Clusiaceae) are widely used for the treatment of mild to moderate depression. Four classes of constituents – hyperforins, hypericins, flavonoids, and xanthones – appear to contribute to the antidepressant activity. Interestingly, all four classes of secondary metabolites involve polyketide derivatives. Key reactions of their biosyntheses are ...

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Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L.

A standardised 50% aqueous ethanolic extract of the Indian variety of Hypericum perforatum (IHp) was examined for its putative anti-inflammatory and analgesic activity at the doses of 100 and 200 mg/kg, po. The experimental paradigms used were carrageenan induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, whereas the tail flick, hot plate and acetic acid ind...

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Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents.

The Iowa Center for Research on Botanical Dietary Supplements seeks to optimize Echinacea, Hypericum, and Prunella botanical supplements for human-health benefit, emphasizing antiviral, anti-inflammatory and anti-pain activities. This mini-review reports on ongoing studies on Hypericum. The Center uses the genetically diverse, well-documented Hypericum populations collected and maintained at th...

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ژورنال

عنوان ژورنال: Phytochemistry

سال: 2011

ISSN: 0031-9422

DOI: 10.1016/j.phytochem.2011.07.016